Description

n-Iodosuccinimide (NIS) is a versatile and highly reactive iodinating agent, essential for introducing iodine atoms into organic molecules with precision and efficiency. Its primary value lies in its ability to perform selective iodination reactions under mild conditions, making it a cornerstone reagent in modern synthetic chemistry. This compound is critically needed by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing active pharmaceutical ingredients (APIs), novel chemical entities, and functional materials.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the iodination of complex molecules in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Research & Development: Used to create iodinated analogs of lead compounds for biological testing and to develop novel pesticides and herbicides.
• Organic Synthesis & Methodology: Employed in fundamental research for developing new iodination reactions, cyclizations, and as a source of electrophilic iodine in various transformations.
• Material Science: Facilitates the synthesis of iodinated monomers and polymers, which can impart specific properties like enhanced refractive index or reactivity for advanced materials.
• Radiochemistry Precursor: Serves as a starting material or intermediate in the preparation of compounds labeled with radioactive iodine isotopes for diagnostic and research applications.
• Fine Chemical Manufacturing: Utilized in the production of specialty iodinated fine chemicals, dyes, and photographic chemicals.

Basic Information

Product Name	n-Iodosuccinimide
CAS No.	516-12-1
Molecular Formula	C4H4INO2
Molecular Weight	224.99 g/mol
Synonyms	N-Iodosuccinimide; 1-Iodopyrrolidine-2,5-dione; Iodosuccinimide; NIS; Succinimide, N-iodo-; NSC 9372
EINECS	208-214-8

Quality Control

Our n-Iodosuccinimide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Each lot is analyzed to confirm identity, purity, and impurity profile. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by iodometric titration), melting point, and heavy metal content is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain optimal reactivity and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (Iodometric Titration)	≥ 98.0 %
Melting Point	195 - 205 °C (with decomposition)
Heavy Metals (as Pb)	≤ 20 ppm
Loss on Drying	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.