Description

(1R,4S)-3,3-Dibromo-1,7,7-Trimethylbicyclo[2.2.1]Heptan-2-One is a high-purity, stereochemically defined brominated derivative of camphor, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the precise spatial arrangement of its bromine atoms and carbonyl group, which enables stereoselective transformations and the construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific chiral centers or functional handles into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the rigid bicyclic framework of camphor.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the dibromo functionality allows for further selective coupling reactions.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in metal-catalyzed asymmetric reactions.
• Organic Synthesis Building Block: Employed in Diels-Alder reactions, nucleophilic substitutions, and reductive dehalogenation sequences to create complex natural product analogs.
• Fragrance and Flavor Chemistry: Utilized as a modified camphor derivative in the research of novel aroma chemicals with unique olfactory properties.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of specialty polymers with specific thermal or optical properties.

Basic Information

Product Name	(1R,4S)-3,3-Dibromo-1,7,7-Trimethylbicyclo[2.2.1]Heptan-2-One
CAS No.	514-12-5
Molecular Formula	C10H14Br2O
Molecular Weight	310.03 g/mol
Synonyms	(1R,4S)-3,3-Dibromocamphor; (+)-3,3-Dibromocamphor; 3,3-Dibromo-(1R,4S)-camphor; 3,3-Dibromocamphor; d-3,3-Dibromocamphor; (1R,4S)-1,7,7-Trimethyl-3,3-dibromobicyclo[2.2.1]heptan-2-one; NSC 403754
EINECS	208-169-0

Quality Control

Our (1R,4S)-3,3-Dibromo-1,7,7-Trimethylbicyclo[2.2.1]Heptan-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	74 - 78 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.