Description

(5Alpha)-7,8-Didehydro-4,5-Epoxy-14-Hydroxy-3-Methoxy-17-Methylmorphinan-6-One is a high-purity pharmaceutical intermediate and reference standard of significant importance in the research and development of active pharmaceutical ingredients (APIs). This compound, also known by its common name Oripavine, is a key precursor in the synthesis of potent opioid analgesics and other specialized pharmaceuticals. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in advanced medicinal chemistry, process development, and quality control.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent opioid analgesics such as buprenorphine and etorphine.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing via HPLC, GC, or LC-MS.
• Medicinal Chemistry Research: Serves as a scaffold for the research and development of new chemical entities with targeted receptor activity.
• Process Development & Scale-Up: Employed in optimizing synthetic routes and manufacturing processes for API production under GMP guidelines.
• Controlled Substance Analysis: Utilized as a certified reference material in forensic and regulatory laboratories for identification and quantification.

Basic Information

Product Name	(5Alpha)-7,8-Didehydro-4,5-Epoxy-14-Hydroxy-3-Methoxy-17-Methylmorphinan-6-One
CAS No.	508-54-3
Molecular Formula	C₁₈H₂₁NO₄
Molecular Weight	315.36 g/mol
Synonyms	Oripavine; 6-Deoxythebaine; 3-O-Demethylthebaine; 4,5α-Epoxy-6,14-ethenomorphinan-3-ol, 17-methyl-; (-)-Oripavine; (5α)-7,8-Didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; 6-O-Demethylthebaine
EINECS	Contact for details

Quality Control

Our Oripavine is manufactured and tested to meet stringent quality standards suitable for pharmaceutical R&D and intermediate use. We provide comprehensive quality assurance, with product specifications typically covering identity, purity, and related substances. Certificates of Analysis (COA) detailing batch-specific results from advanced analytical techniques (HPLC, GC, NMR) are available for every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the substance from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.