Description

(S)-Mephenytoin is the S-enantiomer of the anticonvulsant drug mephenytoin, a hydantoin derivative. This high-purity chiral compound is a critical reference standard and intermediate in pharmaceutical research and development, particularly for studying stereoselective metabolism and pharmacokinetics. It is essential for analytical laboratories, R&D chemists, and manufacturers in the pharmaceutical and life sciences sectors focused on neurology and drug metabolism.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and assay development in pharmaceutical analysis.
• Metabolic Studies: A key substrate for investigating cytochrome P450 (CYP2C19) enzyme activity and genetic polymorphisms in drug metabolism research.
• Chiral Intermediate: Serves as a pure enantiomeric building block for the synthesis of more complex chiral molecules in medicinal chemistry.
• Pharmacological Research: Employed in preclinical studies to understand the stereospecific activity, toxicity, and efficacy of hydantoin-based compounds.
• Analytical Method Development: Used to develop and validate chiral separation methods in HPLC and other analytical techniques.
• Academic Research: Utilized in university and institutional labs for studies in neuropharmacology, enzymology, and organic chemistry.

Basic Information

Product Name	(S)-Mephenytoin
CAS No.	50-12-4
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	(S)-5-Ethyl-3-methyl-5-phenylhydantoin; (S)-Mephenytoin; S-Mephenytoin; (S)-Methoin; (S)-5-Ethyl-1-methyl-5-phenyl-2,4-imidazolidinedione; (S)-3-Methyl-5-ethyl-5-phenylhydantoin; Nirvanol (S-enantiomer); (S)-5-Phenyl-5-ethyl-3-methylhydantoin
EINECS	200-008-1

Quality Control

Our (S)-Mephenytoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and enantiomeric excess. We support compliance with relevant pharmacopeial and research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.