Description

4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carbonitrile is a high-value, heterocyclic organic compound featuring a thiazole core substituted with a trifluoromethylphenyl group and a nitrile functionality. This specific molecular architecture makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules. The compound's unique properties facilitate the development of products with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in areas targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Research: Used as a building block for developing new generations of herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole and trifluoromethyl motifs.
• Material Science: Acts as a monomer or functional additive in the research of advanced polymers, liquid crystals, and organic electronic materials due to its rigid, conjugated structure.
• Chemical Synthesis: Employed as a versatile synthon in organic chemistry for constructing complex heterocyclic systems through cyclization and cross-coupling reactions.
• Life Science Research: Utilized in biochemical research as a probe or inhibitor to study enzyme mechanisms and cellular pathways.

Basic Information

Product Name	4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carbonitrile
CAS No.	499796-94-0
Molecular Formula	C12H7F3N2S
Molecular Weight	268.26 g/mol
Synonyms	5-Cyano-4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole; 2-[4-(Trifluoromethyl)phenyl]-4-methyl-1,3-thiazole-5-carbonitrile; 4-Methyl-2-(4-trifluoromethylphenyl)thiazole-5-carbonitrile; 4-Methyl-2-(α,α,α-trifluoro-p-tolyl)thiazole-5-carbonitrile; 1,3-Thiazole-5-carbonitrile, 4-methyl-2-[4-(trifluoromethyl)phenyl]-; Thiazole derivative CAS 499796-94-0
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports compliance with cGMP standards for pharmaceutical intermediates and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.