Description

Methyl 3-Amino-4-Cyano-5-Piperidinothiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique molecular architecture, featuring amino, cyano, ester, and piperidine-substituted thiophene moieties, provides multiple reactive sites for constructing complex pharmacophores. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly as a key intermediate in medicinal chemistry programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Acts as a building block for advanced organic electronic materials due to the conjugated thiophene system.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	Methyl 3-Amino-4-Cyano-5-Piperidinothiophene-2-Carboxylate
CAS No.	499771-09-4
Molecular Formula	C12H15N3O2S
Molecular Weight	265.33 g/mol
Synonyms	Methyl 3-amino-4-cyano-5-(piperidin-1-yl)thiophene-2-carboxylate; 5-Piperidin-1-yl-3-amino-4-cyanothiophene-2-carboxylic acid methyl ester; 3-Amino-4-cyano-5-piperidino-2-thiophenecarboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 3-amino-4-cyano-5-(1-piperidinyl)-, methyl ester; Methyl 3-amino-4-cyano-5-(1-piperidinyl)thiophene-2-carboxylate; 499771-09-4; 1-Piperidinyl substituted thiophene derivative
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-4-Cyano-5-Piperidinothiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.