Description

1,2-Benzenediol,3-[(1R)-2,2,2-Trifluoro-1-Hydroxyethyl]-(9Ci) is a chiral fluorinated catechol derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for creating molecules with enhanced biological activity and unique physicochemical properties, primarily due to its trifluoromethyl and hydroxyl functional groups. It is needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated compounds for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the introduction of fluorine atoms can enhance activity and environmental profile.
• Asymmetric Catalysis: Serves as a precursor or ligand in catalytic systems for enantioselective synthesis, leveraging its chiral center.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers and advanced materials with specific surface properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on the synthesis and behavior of organofluorine molecules.
• Ligand for Metal Complexation: The catechol moiety makes it a candidate for chelating metal ions in catalytic or sensing applications.

Basic Information

Product Name	1,2-Benzenediol,3-[(1R)-2,2,2-Trifluoro-1-Hydroxyethyl]-(9Ci)
CAS No.	499202-20-9
Molecular Formula	C8H7F3O3
Molecular Weight	208.14 g/mol
Synonyms	(R)-1-(2,3-Dihydroxyphenyl)-2,2,2-trifluoroethanol; 3-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]benzene-1,2-diol; (R)-2,2,2-Trifluoro-1-(2,3-dihydroxyphenyl)ethanol; 1,2-Benzenediol, 3-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-; (R)-Trifluoromethylcatechol ethanol derivative; 499202-20-9; (R)-TFM-Catechol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Specifications can be developed to meet specific customer requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.