Description

2-Boc-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is a high-purity, protected isoquinoline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are central to modern drug discovery. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tetrahydroisoquinoline-based drug candidates, including potential central nervous system (CNS) agents and anticancer compounds.
• Organic Synthesis Building Block: Used for constructing complex molecular architectures in medicinal chemistry and process research, leveraging the Boc-protected amine and carboxylic acid functionalities.
• Peptidomimetic Research: Serves as a constrained scaffold for designing and synthesizing peptide mimics to modulate biological activity and improve metabolic stability.
• Agrochemical Development: Employed in the research phase for creating novel herbicides or pesticides with specific biological targets.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Boc-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid
CAS No.	499139-27-4
Molecular Formula	C16H19NO5
Molecular Weight	305.33 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-1-carboxylic acid]; 2-(tert-Butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 6-Methoxy-2-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; Boc-6-MeO-Tic-OH; 2-Boc-6-OMe-Tic-OH; tert-Butyl 6-methoxy-1-(carboxy)-3,4-dihydro-1H-isoquinoline-2(1H)-carboxylate
EINECS	Contact for details

Quality Control

Our 2-Boc-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.