Description

4-(2-Thienyl)-2,3-Dihydro-1H-1,5-Benzodiazepine is a high-purity benzodiazepine derivative, a key heterocyclic scaffold of significant interest in advanced pharmaceutical research and development. This compound matters as a versatile and critical building block for synthesizing novel active pharmaceutical ingredients (APIs) and for probing structure-activity relationships in medicinal chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents or specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a core structural motif for the synthesis of novel benzodiazepine-based drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a key scaffold in hit-to-lead optimization and library synthesis for high-throughput screening (HTS) campaigns.
• Chemical Biology Probe: Employed in the development of molecular probes to study biological pathways and receptor interactions.
• Agrochemical Development: Acts as a precursor in the research and synthesis of new crop protection agents and pesticides.
• Fine Chemical Synthesis: Utilized as a specialized building block for creating complex molecules in custom synthesis and contract manufacturing.
• Academic Research: Provides a valuable compound for universities and research institutes studying heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	4-(2-Thienyl)-2,3-Dihydro-1H-1,5-Benzodiazepine
CAS No.	497178-55-9
Molecular Formula	C₁₄H₁₂N₂S
Molecular Weight	240.32 g/mol
Synonyms	4-(Thiophen-2-yl)-2,3-dihydro-1H-1,5-benzodiazepine; 1,5-Benzodiazepine, 4-(2-thienyl)-2,3-dihydro-; 4-(2-Thienyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine; 2,3-Dihydro-4-(2-thienyl)-1H-1,5-benzodiazepine; 4-(Thien-2-yl)-2,3-dihydro-1H-1,5-benzodiazepine
EINECS	Contact for details

Quality Control

Our 4-(2-Thienyl)-2,3-Dihydro-1H-1,5-Benzodiazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.