Description

3H-Imidazo[1,2-A]Indol-3-One, 1,2,9,9A-Tetrahydro-9-Hydroxy-2,9-Dimethyl-, (2S,9S,9Ar)- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API intermediate) with the CAS number 496961-88-7. This compound is critical for the synthesis of complex bioactive molecules, offering a precise chiral scaffold for medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new Active Pharmaceutical Ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	3H-Imidazo[1,2-A]Indol-3-One, 1,2,9,9A-Tetrahydro-9-Hydroxy-2,9-Dimethyl-, (2S,9S,9Ar)- (9Ci)
CAS No.	496961-88-7
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	(2S,9S,9aR)-1,2,9,9a-Tetrahydro-9-hydroxy-2,9-dimethyl-3H-imidazo[1,2-a]indol-3-one; (2S,9S,9aR)-9-Hydroxy-2,9-dimethyl-1,2,9,9a-tetrahydro-3H-imidazo[1,2-a]indol-3-one; 9-Hydroxy-2,9-dimethyl-1,2,9,9a-tetrahydro-3H-imidazo[1,2-a]indol-3-one (stereoisomer); Imidazo[1,2-a]indol-3-one derivative; Chiral imidazoindolone; API Intermediate 496961-88-7.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development under cGMP guidelines as required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.