Description

(1S,3S)-5,7,8-Tribromo-1,3-Di(Prop-2-En-1-Yl)-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and halogenated isoquinoline core structure. This compound is critical for the synthesis of complex bioactive molecules, offering a precise chiral scaffold for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Asymmetric Synthesis: Its defined (1S,3S) stereochemistry makes it a valuable precursor for constructing complex molecules with high enantiomeric purity.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying enzyme function and protein-ligand interactions in biological systems.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(1S,3S)-5,7,8-Tribromo-1,3-Di(Prop-2-En-1-Yl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	496882-74-7
Molecular Formula	C₁₇H₁₉Br₃N
Molecular Weight	476.06 g/mol
Synonyms	(1S,3S)-5,7,8-Tribromo-1,3-diallyl-1,2,3,4-tetrahydroisoquinoline; 1,3-Diallyl-5,7,8-tribromo-1,2,3,4-tetrahydroisoquinoline (stereoisomer); (1S,3S)-1,3-Bis(2-propen-1-yl)-5,7,8-tribromo-1,2,3,4-tetrahydroisoquinoline; 5,7,8-Tribromo-1,3-diallyl-tetrahydroisoquinoline (S,S-isomer); Tribromodiallyltetrahydroisoquinoline; CAS 496882-74-7
EINECS	Contact for details

Quality Control

Every batch of (1S,3S)-5,7,8-Tribromo-1,3-Di(Prop-2-En-1-Yl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity consistent with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.