Description

2-Thiazolecarboxylicacid,2,5-Dihydro-5-Methyl-,Methylester,(2R,5R)-Rel-(9Ci) is a high-purity, stereochemically defined thiazole derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its precise stereochemistry and functional groups make it invaluable for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for antiviral, antibacterial, or neurological targets.
• Agrochemical Synthesis: Used in the creation of advanced, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or functional additive for creating specialized polymers with unique electronic or optical properties.
• Academic & Industrial R&D: Employed in methodological studies and process chemistry for developing new synthetic routes to complex heterocycles.

Basic Information

Product Name	2-Thiazolecarboxylicacid,2,5-Dihydro-5-Methyl-,Methylester,(2R,5R)-Rel-(9Ci)
CAS No.	496878-18-3
Molecular Formula	C7H9NO2S
Molecular Weight	171.22 g/mol
Synonyms	(2R,5R)-rel-2,5-Dihydro-5-methyl-2-thiazolecarboxylic acid methyl ester; Methyl (2R,5R)-rel-2,5-dihydro-5-methyl-1,3-thiazole-2-carboxylate; (rel)-(2R,5R)-5-Methyl-4,5-dihydro-1,3-thiazole-2-carboxylic acid methyl ester; 2-Thiazolecarboxylic acid, 2,5-dihydro-5-methyl-, methyl ester, (2R,5R)-rel-; 496878-18-3; Methyl 5-methyl-4,5-dihydro-1,3-thiazole-2-carboxylate (racemic diastereomer)
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, essential for sensitive synthetic applications. Quality is verified through advanced analytical techniques including Chiral HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.