Description

20-(11-Mercaptoundecanyloxy)-3,6,9,12,15,18-Hexaoxaeicosane-1-Amine,Hydrochloride is a specialized heterobifunctional crosslinking agent featuring a terminal thiol (mercapto) group and a primary amine group, separated by a hydrophilic polyethylene glycol (PEG) spacer. This unique molecular architecture is critical for creating stable, oriented conjugations between biomolecules and surfaces, particularly in aqueous environments. It is an essential reagent for researchers and manufacturers in bioconjugation, diagnostic assay development, and advanced material science, where precise and reliable covalent attachment is required.

Application

• Surface Functionalization: Immobilization of proteins, peptides, or antibodies onto gold, silver, or maleimide-activated surfaces for biosensor and microarray fabrication.
• PEGylated Linker for Drug Conjugates: Serving as a heterobifunctional linker in antibody-drug conjugates (ADCs) or peptide-drug conjugates to attach cytotoxic payloads, leveraging the PEG spacer for improved solubility and pharmacokinetics.
• Nanoparticle Conjugation: Covalent attachment of targeting ligands (e.g., antibodies, folates) to gold nanoparticles or quantum dots for targeted imaging and therapeutic applications.
• Hydrogel and Biomaterial Modification: Incorporation into polymer networks to introduce reactive amine sites for further chemical modification or to enhance biocompatibility.
• Affinity Chromatography Resin Preparation: Coupling ligands to chromatographic supports via the amine group for the purification of specific biomolecules.
• Stable Crosslinking in Protein Studies: Creating defined crosslinks between cysteine and lysine residues within or between proteins for structural biology studies or to stabilize protein complexes.

Basic Information

Product Name	20-(11-Mercaptoundecanyloxy)-3,6,9,12,15,18-Hexaoxaeicosane-1-Amine,Hydrochloride
CAS No.	496839-01-1
Molecular Formula	C26H54ClNO7S
Molecular Weight	560.22 g/mol
Synonyms	HS-PEG6-NH2•HCl; 11-Mercaptoundecyl-PEG6-amine hydrochloride; Thiol-PEG6-amine hydrochloride; Heterobifunctional PEG, SH-PEG-NH2 HCl; α-Amino-ω-mercapto heptaethylene glycol undecanyl ether hydrochloride; Amino-PEG6-thiol HCl; 20-Amino-3,6,9,12,15,18-hexaoxaeicosyl 11-mercaptoundecyl ether hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 20-(11-Mercaptoundecanyloxy)-3,6,9,12,15,18-Hexaoxaeicosane-1-Amine,Hydrochloride is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and mass spectrometry to verify structural identity, purity, and functional group integrity. Certificates of Analysis (COA) detailing lot-specific results are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and easily oxidized nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Functional Groups)	≥ 90% (Amino & Thiol)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.