Description

Ethyl 4-(4-((4-Oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)butanamido)benzoate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in vitro to study enzyme inhibition mechanisms and cellular signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Ethyl 4-(4-((4-Oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)butanamido)benzoate
CAS No.	496028-91-2
Molecular Formula	C22H23N3O4S2
Molecular Weight	457.56 g/mol
Synonyms	Ethyl 4-[4-[(4-oxo-5,7-dihydro-6H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]butanoylamino]benzoate; 2-[(4-[[4-(Ethoxycarbonyl)phenyl]amino]-4-oxobutyl)thio]-5,7-dihydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one; Benzoic acid, 4-[[4-[(4-oxo-5,7-dihydro-6H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio]-1-oxobutyl]amino]-, ethyl ester; A thienopyrimidine derivative intermediate.
EINECS	Contact for details

Quality Control

Our Ethyl 4-(4-((4-Oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)butanamido)benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and pre-clinical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.