Description

5(1H)-Indolizinone, Hexahydro-8-Hydroxy-, (8R,8As)- (9Ci) is a high-purity, stereochemically defined heterocyclic compound with the CAS number 494225-05-7. This advanced pharmaceutical intermediate is valued for its complex, fused-ring structure which serves as a critical chiral building block in modern synthetic chemistry. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and anti-infective drugs.
• Asymmetric Synthesis: Utilized as a sophisticated building block for constructing complex molecules with high stereochemical purity in academic and industrial research.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value compounds requiring precise stereocontrol.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of complex target molecules.

Basic Information

Item	Details
Product Name	5(1H)-Indolizinone, Hexahydro-8-Hydroxy-, (8R,8As)- (9Ci)
CAS No.	494225-05-7
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	(8R,8aS)-Hexahydro-8-hydroxy-5(1H)-indolizinone; (8R,8aS)-Octahydro-8-hydroxy-1H-indolizin-5-one; Hexahydro-8-hydroxy-5(1H)-indolizinone, (8R,8aS)-; 494225-05-7; (8R,8aS)-8-Hydroxyoctahydroindolizin-5-one; (8R,8aS)-8-Hydroxyhexahydro-1H-indolizin-5-one; (8R,8aS)-8-Hydroxy-1,2,3,6,7,8-hexahydro-5H-indolizin-5-one
EINECS	Contact for details

Quality Control

Our 5(1H)-Indolizinone, Hexahydro-8-Hydroxy-, (8R,8As)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.