Description

tert-Butyl(4-(3-(Dimethoxyphosphoryl)-2-Oxopropyl)Phenyl)Carbamate is a specialized organophosphorus building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical research and agrochemical discovery. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries seeking to incorporate phosphoryl and ketone functionalities into target structures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition or other phosphonate-containing therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, insecticides, and plant growth regulators that leverage its unique phosphoryl moiety.
• Chemical Biology Probe Development: Serves as a precursor for creating labeled compounds or activity-based probes to study enzymatic pathways and protein function.
• Ligand and Catalyst Precursor: Employed in the preparation of sophisticated ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Peptidomimetic and PROTAC Synthesis: Utilized as a key fragment in constructing complex peptidomimetics and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with specific functional properties.

Basic Information

Product Name	tert-Butyl(4-(3-(Dimethoxyphosphoryl)-2-Oxopropyl)Phenyl)Carbamate
CAS No.	494224-44-1
Molecular Formula	C16H24NO6P
Molecular Weight	357.34 g/mol
Synonyms	Boc-4-(3-(Dimethoxyphosphoryl)-2-oxopropyl)aniline; 1-{4-[(tert-Butoxycarbonyl)amino]phenyl}-3-(dimethoxyphosphoryl)propan-2-one; tert-Butyl N-[4-[3-(dimethoxyphosphoryl)-2-oxopropyl]phenyl]carbamate; 4-(Boc-amino)phenyl-3-(dimethoxyphosphoryl)-2-propanone; (Dimethoxyphosphoryl)acetone Boc-aniline derivative; CAS 494224-44-1
EINECS	Contact for details

Quality Control

Our tert-Butyl(4-(3-(Dimethoxyphosphoryl)-2-Oxopropyl)Phenyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.