Description

Carbamic Acid, [(6S,8As)-1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Octahydro-5-Oxo-6-Indolizinyl]-, 1,1-Dimethylethyl Ester (9Ci) is a sophisticated, high-purity synthetic intermediate featuring a protected indolizidine core structure. This compound is of critical importance for its role as a key chiral building block in the synthesis of complex pharmaceutical agents, particularly those targeting neurological and infectious diseases. It is primarily needed by research institutions and pharmaceutical development teams engaged in the creation of novel therapeutic candidates and process chemistry optimization.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of potent alkaloid-based drug candidates.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive molecules, particularly for central nervous system (CNS) targets.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective reactions to construct complex molecular architectures.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.
• Academic & Industrial R&D: Supports fundamental organic chemistry research and the discovery of new synthetic methodologies.

Basic Information

Product Name	Carbamic Acid, [(6S,8As)-1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Octahydro-5-Oxo-6-Indolizinyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	488083-07-4
Molecular Formula	C19H35NO4Si
Molecular Weight	369.58 g/mol
Synonyms	tert-Butyl N-[(6S,8aS)-1-[(tert-butyldimethylsilyl)oxy]-5-oxooctahydro-6-indolizinyl]carbamate; (6S,8aS)-1-[(tert-Butyldimethylsilyl)oxy]-5-oxooctahydroindolizine-6-carboxylic acid tert-butylamide; tert-Butyl ((6S,8aS)-1-((tert-butyldimethylsilyl)oxy)-5-oxooctahydro-6-indolizinyl)carbamate; TBDMS-protected indolizidine carbamate; CAS 488083-07-4
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.