Description

1,2,3,4-Tetrahydro-Isoquinolin-4-Ylamine Dihydrochloride is a high-purity, pharmaceutically relevant organic salt, serving as a critical building block in advanced chemical synthesis. This compound matters for its role as a versatile intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on medicinal chemistry, particularly in the synthesis of compounds targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the synthesis of complex heterocyclic compounds for biological screening.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and other complex organic molecules.
• Academic & Contract Research: Serves as a valuable reagent in university laboratories and CROs (Contract Research Organizations) for exploratory synthetic projects.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial production.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinolin-4-Ylamine Dihydrochloride
CAS No.	486453-50-3
Molecular Formula	C9H14N2·2HCl
Molecular Weight	231.14 g/mol
Synonyms	4-Amino-1,2,3,4-tetrahydroisoquinoline dihydrochloride; 1,2,3,4-Tetrahydro-4-isoquinolinamine dihydrochloride; 4-Aminotetrahydroisoquinoline dihydrochloride; THIQ-4-amine dihydrochloride; 4-ATIQ dihydrochloride; (1,2,3,4-Tetrahydroisoquinolin-4-yl)amine dihydrochloride; 4-Amino-THIQ·2HCl
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinolin-4-Ylamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.