Description

2-Thiophenecarboxamide, 5-Chloro-n-[2-Hydroxy-3-[[3-Methyl-4-(3-Oxo-4-Morpholinyl)Phenyl]Amino]Propyl]- is a sophisticated heterocyclic organic compound featuring a thiophene core linked to a morpholinone-substituted aniline moiety via a hydroxypropyl spacer. This complex structure makes it a valuable advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules, particularly those targeting specific enzyme pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for research into kinase inhibitors and other targeted therapies.
• Biochemical Research: Used as a reference standard or a key reactant in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Organic Synthesis: Employed in multi-step synthetic routes to construct complex molecular architectures containing thiophene and morpholine pharmacophores.
• Life Science Reagent: Acts as a specialized reagent or precursor in the development of diagnostic compounds or molecular probes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	2-Thiophenecarboxamide, 5-Chloro-n-[2-Hydroxy-3-[[3-Methyl-4-(3-Oxo-4-Morpholinyl)Phenyl]Amino]Propyl]-
CAS No.	482306-16-1
Molecular Formula	C19H22ClN3O3S
Molecular Weight	407.91 g/mol
Synonyms	5-Chloro-N-[2-hydroxy-3-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-2-thiophenecarboxamide; 5-Chloro-N-(2-hydroxy-3-((3-methyl-4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide; 482306-16-1; UNII-6W7Q4F4J34; 6W7Q4F4J34; Thiophene-2-carboxamide, 5-chloro-N-[2-hydroxy-3-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-; AKOS025310924; CS-0236602.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters including assay, related substances, and residual solvents. We support development and commercial projects with material produced under quality-controlled or cGMP-like conditions, as required.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container should be stored in a cool, dry place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.