Description

Dirlotapide CAS NO 481658-94-0 is a selective microsomal triglyceride transfer protein (MTP) inhibitor. This compound is of significant interest in pharmaceutical research and development, particularly for its role in lipid metabolism regulation. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing therapeutic agents for metabolic disorders, including obesity and dyslipidemia.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or intermediate in the synthesis of therapeutic drugs targeting lipid absorption.
• Metabolic Disorder Research: Used as a reference standard and research tool in preclinical and clinical studies investigating obesity, hyperlipidemia, and related metabolic syndromes.
• Veterinary Medicine Development: Applied in the formulation of weight management solutions for companion animals, such as dogs.
• Biochemical Pathway Analysis: Employed in laboratory settings to study the mechanism of action of MTP inhibitors and intestinal fat absorption.
• Drug Discovery & Development: Integral to medicinal chemistry programs aiming to discover novel analogs with improved efficacy and safety profiles.

Basic Information

Product Name	Dirlotapide
CAS No.	481658-94-0
Molecular Formula	C39H38F3NO4
Molecular Weight	641.72 g/mol
Synonyms	N-[(1S,2S)-1-(4-Fluorophenyl)-3-[(2S)-2-[(4-fluorophenyl)formamido]-1-oxo-3-phenylpropyl]amino-2-hydroxy-1-(4-methoxyphenyl)propyl]-2,2,2-trifluoroacetamide; Dirlotapide free base; SLx-4090; 1-(4-Fluorophenyl)-3-[(2S)-2-[(4-fluorophenyl)formamido]-1-oxo-3-phenylpropyl]amino-2-hydroxy-1-(4-methoxyphenyl)propyl 2,2,2-trifluoroacetate (S,S)-isomer
EINECS	Contact for details

Quality Control

Our Dirlotapide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.