Description

3-Chloro-5-Fluoro-1H-Indole-2-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated indole scaffold makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potent drug candidates, particularly in oncology, neurology, and anti-inflammatory research.
• Agrochemical Development: Used in creating novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated indole core.
• Chemical Research & Development: Serves as a versatile building block for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Material Science Precursor: Potential use in synthesizing specialized organic ligands, dyes, and functional polymers.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for scale-up and production under cGMP conditions.

Basic Information

Product Name	3-Chloro-5-Fluoro-1H-Indole-2-Carboxylic Acid
CAS No.	480450-96-2
Molecular Formula	C9H5ClFNO2
Molecular Weight	213.59 g/mol
Synonyms	3-Chloro-5-fluoro-1H-indole-2-carboxylic acid; 2-Carboxy-3-chloro-5-fluoroindole; 480450-96-2; 3-Chloro-5-fluoroindole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 3-chloro-5-fluoro-; 3-Cl-5-F-1H-Indole-2-COOH
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Fluoro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, NMR, and MS data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.