Description

(2,4-Difluorophenylethynyl)trimethylsilane is a high-purity organosilicon intermediate featuring a difluorophenylacetylene moiety. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor in the development of organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: An effective substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to construct complex molecular architectures.
• Fluorine Chemistry: A valuable reagent for introducing fluorinated phenylethynyl groups into target molecules, modulating their electronic and physical properties.

Basic Information

Product Name	(2,4-Difluorophenylethynyl)trimethylsilane
CAS No.	480438-92-4
Molecular Formula	C11H12F2Si
Molecular Weight	210.30 g/mol
Synonyms	Trimethyl[(2,4-difluorophenyl)ethynyl]silane; 1-[(Trimethylsilyl)ethynyl]-2,4-difluorobenzene; 2,4-Difluorophenylacetylene trimethylsilyl ether; (2,4-Difluorophenyl)ethynyltrimethylsilane; TMS-2,4-difluorophenylacetylene
EINECS	Contact for details

Quality Control

Our (2,4-Difluorophenylethynyl)trimethylsilane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.