Description

γ-Butyrobetaine-D9 is a stable isotope-labeled analog of γ-butyrobetaine, a key intermediate in the biosynthesis of L-carnitine. This deuterated compound is essential for precise quantitative analysis and metabolic pathway studies, offering unmatched accuracy as an internal standard in mass spectrometry. It is primarily required by pharmaceutical researchers, clinical diagnostic laboratories, and contract research organizations (CROs) engaged in advanced metabolomics and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous γ-butyrobetaine and related metabolites in biological matrices like plasma, serum, and urine.
• Metabolomics Research: Used in stable isotope dilution assays to study carnitine biosynthesis pathways, enzyme kinetics, and metabolic flux analysis.
• Clinical Diagnostics Development: Enables the development and validation of high-precision diagnostic assays for inborn errors of metabolism, such as primary carnitine deficiency.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Employed in drug development to trace the metabolic fate of compounds affecting carnitine metabolism.
• Biomarker Discovery and Validation: Serves as a reference compound in the identification and verification of new biomarkers related to cardiovascular, renal, and muscular disorders.
• Quality Control in Reference Material Production: Used to certify and calibrate reference materials and kits for clinical testing.

Basic Information

Product Name	γ-Butyrobetaine-D9
CAS No.	479677-53-7
Molecular Formula	C7D9H6NO3
Molecular Weight	161.20 g/mol (deuterated form)
Synonyms	4-(Trimethylammonio)-D9-butanoate; 3-Carboxy-N,N,N-trimethyl-D9-propanaminium inner salt; γ-Butyrobetaine-d9; (3-Carboxypropyl)trimethylammonium-d9 hydroxide inner salt; 4-(N,N,N-Trimethylammonio)butyrate-d9; L-Carnitine precursor-d9; BBD9; GBB-D9
EINECS	Contact for details

Quality Control

Our γ-Butyrobetaine-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to relevant standards for high-purity reference materials to guarantee reliable and reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.