Description

Methyl 2-(7-Nitro-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate is a specialized organic compound featuring a tetrahydroisoquinoline core functionalized with a nitro group and an ester moiety. This molecular architecture makes it a valuable key intermediate and building block in advanced synthetic chemistry. It is primarily sought after by research institutions and pharmaceutical developers engaged in the synthesis of complex nitrogen-containing heterocycles, which are prevalent in active pharmaceutical ingredients (APIs) and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Organic Synthesis Building Block: Used for constructing complex tetrahydroisoquinoline-based scaffolds, a privileged structure in medicinal chemistry.
• Research & Development (R&D): Employed in academic and industrial R&D settings for method development and exploring new chemical entities.
• Agrochemical Research: Potential intermediate in the development of new herbicides or plant growth regulators due to its heterocyclic structure.
• Material Science Precursor: Can be utilized in the synthesis of specialty chemicals, dyes, or ligands for catalytic systems.

Basic Information

Product Name	Methyl 2-(7-Nitro-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate
CAS No.	479664-43-2
Molecular Formula	C₁₂H₁₄N₂O₄
Molecular Weight	250.25 g/mol
Synonyms	Methyl (7-nitro-1,2,3,4-tetrahydro-1-isoquinolinyl)acetate; 1,2,3,4-Tetrahydro-7-nitro-1-isoquinolineacetic acid methyl ester; Methyl 2-(7-nitro-3,4-dihydro-1H-isoquinolin-1-yl)acetate; 479664-43-2; Methyl (7-nitro-3,4-dihydro-1H-isoquinolin-1-yl)acetate; 7-Nitro-1,2,3,4-tetrahydroisoquinoline-1-acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2-(7-Nitro-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.