Description

4-Bromo-2-(n-Boc-Aminomethyl)Thiophene is a high-purity, protected amino-thiophene derivative of significant importance in advanced organic synthesis. This compound serves as a versatile and critical building block for the construction of complex heterocyclic molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates targeting various therapeutic areas, including central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the thiophene moiety for enhanced biological activity.
• Material Science Precursor: Employed in the synthesis of organic semiconductors, conductive polymers, and liquid crystals due to the electronic properties of the thiophene ring.
• Peptidomimetics & Bioconjugation: The protected amine group allows for its incorporation into peptide analogs or its use as a linker for bioconjugation strategies.
• Chemical Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.

Basic Information

Product Name	4-Bromo-2-(n-Boc-Aminomethyl)Thiophene
CAS No.	479090-39-6
Molecular Formula	C10H14BrNO2S
Molecular Weight	292.19 g/mol
Synonyms	2-((tert-Butoxycarbonylamino)methyl)-4-bromothiophene; 4-Bromo-2-((tert-butoxycarbonylamino)methyl)thiophene; 4-Bromo-2-(Boc-aminomethyl)thiophene; tert-Butyl (4-bromothiophen-2-yl)methylcarbamate; Boc-4-Bromo-2-aminomethylthiophene; N-Boc-2-Aminomethyl-4-bromothiophene; 479090-39-6; 4-Br-2-(Boc-NH-CH2)-Thiophene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(n-Boc-Aminomethyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be stored away from light. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.