Description

Monobutyl Phthalate-D4 is a deuterium-labeled isotopologue of monobutyl phthalate, a key metabolite and environmental degradant of common phthalate plasticizers. This compound is essential for high-precision analytical work, serving as a critical internal standard for accurate quantification and method validation in mass spectrometry. It is primarily needed by analytical laboratories, environmental testing facilities, and pharmaceutical R&D departments engaged in trace-level analysis of phthalate exposure and metabolism.

Application

• Internal Standard for LC-MS/MS and GC-MS: Provides unmatched accuracy in the quantification of monobutyl phthalate and related phthalate metabolites in complex biological and environmental matrices.
• Biomonitoring and Exposure Assessment: Enables reliable human health studies by measuring urinary or serum levels of phthalate metabolites for toxicological and epidemiological research.
• Environmental Fate and Degradation Studies: Used as a tracer to study the breakdown pathways and persistence of dibutyl phthalate (DBP) and other phthalate esters in environmental systems.
• Pharmaceutical Impurity Profiling: Assists in the detection and quantification of potential genotoxic impurities derived from phthalates in drug substances and products.
• Method Development and Validation: Critical for establishing robust, sensitive, and specific analytical methods compliant with FDA, EPA, and other regulatory guidelines.
• Quality Control in Reference Material Production: Serves as a certified component in the preparation of high-purity reference standards and proficiency testing materials.

Basic Information

Item	Detail
Product Name	Monobutyl Phthalate-D4
CAS No.	478954-81-3
Molecular Formula	C12H8D4O4
Molecular Weight	224.22 g/mol
Synonyms	Butyl Hydrogen Phthalate-d4; Mono-n-butyl Phthalate-d4; MBP-d4; Phthalic Acid Monobutyl Ester-d4; 1-Butyl Hydrogen Phthalate-d4; Deuterated Monobutyl Phthalate; [2H4]-Monobutyl Phthalate; MBzP-d4 (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of Monobutyl Phthalate-D4 is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry to confirm deuteration level and structural identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and solvent content to ensure consistency and reliability for your critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.