Description

1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-5-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core protected by a tetrahydropyranyl (THP) group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile amine handle for further functionalization in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted small-molecule drugs and investigational new chemical entities (NCEs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its reactive amine functionality.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of heterobifunctional degraders.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying enzyme function and cellular pathways.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and scale-up development.
• Academic Research: Employed in university laboratories for novel heterocyclic chemistry and synthetic methodology development.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-5-Amine
CAS No.	478832-10-9
Molecular Formula	C12H15N3O
Molecular Weight	217.27 g/mol
Synonyms	5-Amino-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1H-Indazol-5-amine, 1-(tetrahydro-2H-pyran-2-yl)-; 1-(Oxan-2-yl)-1H-indazol-5-amine; 1-THP-1H-indazol-5-amine; 5-Amino-1-THP-indazole; 478832-10-9; 1-(Tetrahydro-2-pyranyl)-1H-indazol-5-ylamine
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-5-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.