Description

D-[4,5,6,6'-2H4]Glucose is a stable isotope-labeled analog of D-glucose, specifically deuterated at four positions. This high-purity compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose utilization pathways. It is a critical tool for researchers and scientists in pharmaceutical development, clinical diagnostics, and biochemistry who require reliable, isotopically pure materials for mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates in cell cultures and tissues.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard for the accurate LC-MS/MS quantification of glucose and its metabolites in biological matrices.
• Clinical Research: Enables studies on glucose metabolism disorders, such as diabetes and cancer metabolism.
• Biochemical Research: A key reagent for investigating enzyme mechanisms (e.g., hexokinase, glucose-6-phosphate dehydrogenase) using NMR spectroscopy.
• Stable Isotope Labeling: Used in the synthesis of more complex deuterated molecules for research purposes.

Basic Information

Product Name	D-[4,5,6,6'-2H4]Glucose
CAS No.	478529-49-6
Molecular Formula	C6H8D4O6
Molecular Weight	184.18 g/mol
Synonyms	D-Glucose-4,5,6,6-d4; Deuterated D-Glucose; [4,5,6,6'-2H4]-D-Glucopyranose; 1,2,3-Trihydroxy-4,5,6,6-tetradeuterohexanal; D-Glucose (4,5,6,6-d4); Stable Isotope-Labeled Glucose; Glucose-d4
EINECS	Contact for details

Quality Control

Every batch of D-[4,5,6,6'-2H4]Glucose is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for research-grade stable isotope-labeled compounds. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment (by 1H NMR and/or MS), and impurity profile is provided with each shipment to ensure traceability and reliability for your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.