Description

D-Glucose-4,5-D2 is a stable isotope-labeled analog of D-glucose, specifically deuterated at the 4 and 5 positions. This high-purity compound is essential for advanced research and analytical applications where precise metabolic tracing is required. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and analytical laboratories in the fields of metabolic pathway analysis, drug development, and mass spectrometry-based quantification.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotope tracer to study central carbon metabolism and quantify intracellular reaction rates in biological systems.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS methods for the accurate quantification of glucose and its metabolites in biological matrices.
• Biochemical Research: Enables detailed investigation of glycolysis, the pentose phosphate pathway, and other glucose-utilizing metabolic networks.
• Diagnostic Assay Development: Employed in the development of high-sensitivity clinical assays for metabolic disorders like diabetes.
• Nutritional Science Studies: Facilitates the study of glucose absorption, utilization, and turnover in nutritional and physiological research.
• Isotope Dilution Mass Spectrometry (IDMS): Acts as a critical reference standard for achieving high accuracy and precision in quantitative mass spectrometry.

Basic Information

Product Name	D-Glucose-4,5-D2
CAS No.	478529-48-5
Molecular Formula	C6H10D2O6
Molecular Weight	182.17 g/mol
Synonyms	D-Glucose-4,5-dideutero; [4,5-2H2]-D-Glucose; Deuterated D-Glucose (4,5-D2); 4,5-Dideutero-D-glucose; D-(+)-Glucose-4,5-D2; α-D-Glucopyranose-4,5-D2; Stable Isotope Labeled D-Glucose
EINECS	Contact for details

Quality Control

Our D-Glucose-4,5-D2 is manufactured under strict quality management systems to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm isotopic enrichment, chemical identity, and purity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (e.g., D-enrichment at 4,5 positions), chemical purity, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D (at 4,5 positions)
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	+52.0° to +53.0° (c=10 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.