Description

D-[4-2H]Galactose is a stable isotope-labeled analog of the monosaccharide galactose, specifically deuterated at the 4-position. This compound is an essential tool in metabolic research and pharmaceutical development, enabling precise tracking and quantification of galactose metabolism and related biochemical pathways. It is primarily used by researchers and manufacturers in the fields of pharmaceutical development, clinical diagnostics, and academic biochemistry.

Application

• Metabolic Tracer Studies: Used as a stable isotope tracer in in vitro and in vivo research to elucidate galactose metabolic pathways, including the Leloir pathway.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS analyses for the accurate quantification of galactose and its metabolites in biological samples.
• Diagnostic Reagent Development: A key component in the formulation of assay kits for diagnosing metabolic disorders such as galactosemia.
• Biochemical Research: Employed in enzymatic studies to investigate the kinetics and mechanisms of galactose-metabolizing enzymes like galactokinase and galactose-1-phosphate uridylyltransferase.
• Nutritional Science: Used in studies examining galactose absorption, utilization, and its role in human nutrition and lactose metabolism.
• Pharmaceutical Synthesis: Acts as a labeled building block for the synthesis of deuterated glycoproteins, glycolipids, or other complex carbohydrates for research purposes.

Basic Information

Product Name	D-[4-2H]Galactose
CAS No.	478518-71-7
Molecular Formula	C6H11DO6
Molecular Weight	181.16 g/mol
Synonyms	4-Deutero-D-galactose; D-Galactose-4-d; [4-2H]Galactose; Deuterated D-galactose; Galactose-d1; 4-Deuterio-D-galactopyranose; (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal-4-d; Stable Isotope Labeled Galactose
EINECS	Contact for details

Quality Control

Our D-[4-2H]Galactose is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry, to confirm chemical identity, isotopic purity (deuteration level), and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration at C-4)	≥ 98 atom % D
Specific Optical Rotation	+78° to +82° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.