Description

D-[4,5,6,6'-2H4]Fructose is a stable isotope-labeled analog of the natural sugar fructose, where four hydrogen atoms at specific positions have been replaced with deuterium (²H). This high-purity labeled compound is essential for advanced analytical research, enabling precise metabolic pathway tracing and quantification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutritional science, and biochemistry sectors for applications requiring isotopic internal standards.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS and GC-MS analysis of fructose and related metabolites in biological samples.
• Metabolic Flux Analysis (MFA): Used to trace and model carbon and hydrogen flux through metabolic pathways like glycolysis and the pentose phosphate pathway.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies for compounds interacting with sugar metabolism.
• Nutritional Science Studies: Enables detailed investigation of fructose absorption, distribution, and metabolism in clinical and preclinical research.
• Biochemical Research: Acts as a tracer in enzymology studies to elucidate enzyme mechanisms and kinetics involving fructose.
• Diagnostic Assay Development: Employed in the calibration and validation of high-sensitivity diagnostic tests for metabolic disorders.

Basic Information

Product Name	D-[4,5,6,6'-2H4]Fructose
CAS No.	478518-49-9
Molecular Formula	C₆H₈D₄O₆
Molecular Weight	184.18 g/mol
Synonyms	D-Fructose-4,5,6,6'-d4; [4,5,6,6'-²H₄]-D-Fructose; Deuterated D-Fructose; Fructose-d4; Levulose-d4; Fruit Sugar-d4; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-4,5,6,6-d4
EINECS	Contact for details

Quality Control

Every batch of D-[4,5,6,6'-2H4]Fructose is manufactured and analyzed under strict quality management systems to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical methods (NMR, MS, HPLC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.