Description

D-[4,5-2H2]Fructose is a stable isotope-labeled analog of fructose, specifically deuterated at the 4 and 5 positions, with the CAS number 478518-48-8. This compound is an essential tool for advanced metabolic research, enabling precise tracking and quantification of fructose pathways using techniques like mass spectrometry and NMR. It is primarily required by research institutions, pharmaceutical companies, and diagnostic laboratories engaged in carbohydrate metabolism studies, tracer analysis, and the development of new analytical methods.

Application

• Metabolic Tracer Studies: Used as an internal standard in quantitative mass spectrometry (MS) to study fructose absorption, metabolism, and flux in biological systems.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a stable isotope-labeled standard in LC-MS/MS assays for the bioanalysis of fructose and related metabolites in preclinical and clinical research.
• NMR Spectroscopy: Acts as a deuterated probe for structural and dynamic studies of carbohydrate interactions and enzymatic mechanisms without signal interference.
• Clinical Diagnostics Development: Employed in the calibration and validation of diagnostic assays targeting metabolic disorders like diabetes and hereditary fructose intolerance.
• Nutritional Science Research: Facilitates precise investigation into the metabolic fate of dietary fructose in model organisms and human studies.
• Biochemical Pathway Analysis: Enables detailed mapping of glycolytic and fructolytic pathways in cell culture and tissue samples.

Basic Information

Product Name	D-[4,5-2H2]Fructose
CAS No.	478518-48-8
Molecular Formula	C6H10D2O6
Molecular Weight	182.17 g/mol
Synonyms	D-Fructose-4,5-d2; [4,5-2H2]-D-Fructose; Deuterated Fructose; Fructose-d2; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-4,5-d2; Levulose-d2; Fruit Sugar-d2; Stable Isotope Labeled Fructose
EINECS	Contact for details

Quality Control

Our D-[4,5-2H2]Fructose is produced under strict quality management protocols. Each batch is characterized and tested to ensure high chemical and isotopic purity, meeting the stringent requirements for research and analytical applications. Comprehensive Certificates of Analysis (COA) are provided, detailing parameters such as isotopic enrichment (atom % D), chemical purity by HPLC, and specific optical rotation. We support compliance with relevant quality frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % D)	≥ 98% (by NMR or MS)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.