Description

2-Deoxy-D-[5,5'-2H2]Erythro-Pentose is a deuterium-labeled derivative of 2-deoxy-D-ribose, a fundamental sugar moiety in DNA. This isotopically labeled compound is critical for advanced research and development, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in drug discovery, metabolic pathway analysis, and the synthesis of labeled nucleosides and nucleotides.

Application

• Pharmaceutical Research & Drug Development: As a stable isotope-labeled precursor for synthesizing deuterated nucleosides and nucleotides used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Metabolic Pathway Tracing: Employed as a tracer in mass spectrometry-based assays to investigate the pentose phosphate pathway and other sugar metabolism routes in biological systems.
• Biochemical & Structural Biology: Used in NMR spectroscopy to study the structure, dynamics, and interactions of nucleic acids and related enzymes without isotopic interference.
• Diagnostic Reagent Synthesis: A key building block in the production of labeled probes and reagents for in vitro diagnostics and imaging applications.
• Academic Research: Fundamental tool for chemical biology and medicinal chemistry projects focusing on nucleic acid chemistry and isotope effects.

Basic Information

Product Name	2-Deoxy-D-[5,5'-2H2]Erythro-Pentose
CAS No.	478511-68-1
Molecular Formula	C5H8D2O4
Molecular Weight	136.15 g/mol
Synonyms	2-Deoxy-D-ribose-5,5-d2; [5,5-2H2]-2-Deoxy-D-erythro-pentose; 2-Deoxy-D-ribose-d2 (5,5'); Deuterated 2-Deoxyribose; 2-Deoxy-D-arabinose-5,5-d2; 2-Deoxy-D-erythro-pentofuranose-5,5-d2; D-2-Deoxyribose-5,5-d2
EINECS	Contact for details

Quality Control

Our 2-Deoxy-D-[5,5'-2H2]Erythro-Pentose is manufactured under strict quality systems to ensure high isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D atom %), chemical purity by HPLC, and specific optical rotation. We adhere to cGMP guidelines for the production of research-grade labeled compounds, ensuring traceability and consistency for critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D atom %)	≥ 98.0% at C-5
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.