Description

D-[5,5'-2H2]Ribose is a stable isotope-labeled derivative of the essential pentose sugar, D-ribose, specifically deuterated at the 5 and 5' positions. This precise labeling makes it an invaluable internal standard and tracer for advanced analytical and metabolic research. It is primarily utilized by scientists and manufacturers in the pharmaceutical and biotechnology sectors for applications requiring high isotopic purity and chemical stability.

Application

• Metabolic Pathway Analysis: Used as a stable isotope tracer in NMR and mass spectrometry studies to elucidate ribose metabolism and nucleotide biosynthesis pathways.
• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate quantification of endogenous D-ribose and related metabolites in complex biological matrices via LC-MS/MS.
• Pharmaceutical R&D: Employed in the development and validation of analytical methods for novel nucleoside-based therapeutics, including antiviral and anticancer drugs.
• Isotope-Labeled Compound Synthesis: Acts as a key chiral building block for the synthesis of more complex deuterated molecules for research and diagnostic purposes.
• Biochemical Research: Facilitates studies on enzyme kinetics, protein-sugar interactions, and the role of ribose in glycosylation processes.

Basic Information

Product Name	D-[5,5'-2H2]Ribose
CAS No.	478506-32-0
Molecular Formula	C5H8D2O5
Molecular Weight	152.15 g/mol
Synonyms	D-Ribose-5,5-d2; (2R,3R,4R)-5,5-Dideuterio-2,3,4,5-tetrahydroxypentanal; Deuterated D-Ribose; D-Ribose (5,5-d2); Stable Isotope Labeled D-Ribose; [5,5-²H₂]-D-Ribose; Ribose-d2
EINECS	Contact for details

Quality Control

Every batch of D-[5,5'-2H2]Ribose is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) specifying purity, isotopic enrichment, and impurity profiles is provided with each shipment to ensure it meets the exacting standards of research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.