Description

D-[4-2H]Ribose is a stable isotope-labeled derivative of the essential pentose sugar, D-ribose, specifically deuterated at the 4-position. This compound is a critical tool for advanced research in metabolic pathway analysis, drug metabolism studies, and NMR spectroscopy, providing a non-radioactive tracer with high detection sensitivity. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers focused on biochemistry and medicinal chemistry.

Application

• Metabolic Tracer Studies: Used in in vitro and in vivo research to trace the incorporation of ribose into nucleotides, coenzymes, and glycans.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS assays for the quantitative analysis of ribose-containing drug molecules and their metabolites.
• NMR Spectroscopy: The deuterium label facilitates complex structural and dynamic studies of biomolecules by simplifying spectra and allowing for specific probing of molecular interactions.
• Biochemical Pathway Elucidation: Investigates the pentose phosphate pathway and nucleotide synthesis mechanisms in cell culture and model organisms.
• Stable Isotope Labeling: Enables the production of specifically labeled proteins, RNA, and other macromolecules for structural biology applications.
• Diagnostic Agent Development: Potential use in the research and development of novel diagnostic probes and imaging agents.

Basic Information

Product Name	D-[4-2H]Ribose
CAS No.	478506-29-5
Molecular Formula	C5H9D1O5
Molecular Weight	151.13 g/mol
Synonyms	4-Deutero-D-ribose; D-Ribose-4-d; (2R,3R,4R)-2,3,4-Trihydroxy-4-deuteropentanal; 4-Deutero-D-(-)-Ribose; Deuterated D-Ribose; Stable Isotope Labeled Ribose; Ribose-4-d1; [4-2H]-D-Ribose
EINECS	Contact for details

Quality Control

Our D-[4-2H]Ribose is manufactured under controlled conditions to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 2H), chemical purity by HPLC, and specific optical rotation. We adhere to stringent internal quality standards to guarantee batch-to-batch consistency and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 2H)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.