Description

Isoquinoline, 2-(Chlorodifluoroacetyl)-1,2,3,4-Tetrahydro- (9Ci) CAS NO 478258-78-5 is a specialized heterocyclic building block featuring a chlorodifluoroacetyl functional group. This compound is valued for its role as a key synthetic intermediate in the development of complex organic molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, where its unique structure enables the introduction of difluoromethyl and carbonyl motifs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the difluoroacetyl group can enhance biological activity and metabolic stability.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing complex isoquinoline-based heterocycles in academic and industrial research laboratories.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials, such as ligands for catalysis or organic electronic components.

Basic Information

Product Name	Isoquinoline, 2-(Chlorodifluoroacetyl)-1,2,3,4-Tetrahydro- (9Ci)
CAS No.	478258-78-5
Molecular Formula	C11H10ClF2NO
Molecular Weight	245.65 g/mol
Synonyms	2-(Chlorodifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydroisoquinoline-2-carbonyl chloride, 2-difluoro-; 2-(Chlorodifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline (9CI); Tetrahydroisoquinoline-2-carbonyl chloride, 2-difluoro-; 478258-78-5
EINECS	Contact for details

Quality Control

Our Isoquinoline, 2-(Chlorodifluoroacetyl)-1,2,3,4-Tetrahydro- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.