Description

2-Methyl-1,4-Naphthoquinone-D8 is a deuterated analog of menadione, a synthetic form of vitamin K3, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for advanced analytical and research applications requiring high specificity and minimal background interference. It is primarily utilized by researchers and manufacturers in the pharmaceutical, analytical chemistry, and life science sectors for use as an internal standard in mass spectrometry, metabolic studies, and pharmacokinetic research.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantitative analysis of menadione and related compounds.
• Critical component in deuterium-labeled tracer studies for investigating vitamin K metabolism, biosynthesis, and pharmacokinetic profiles.
• Facilitates drug metabolism and disposition (DMPK) studies in pharmaceutical research and development.
• Enables precise bioanalytical method development and validation in clinical and forensic toxicology.
• Used in stable isotope dilution assays to ensure accuracy and reproducibility in complex biological matrices.
• Supports academic and industrial research focused on the biochemical roles of quinones and vitamin K-dependent processes.

Basic Information

Product Name	2-Methyl-1,4-Naphthoquinone-D8
CAS No.	478171-80-1
Molecular Formula	C11D8O2
Molecular Weight	180.24 g/mol
Synonyms	Menadione-d8; Vitamin K3-d8; 2-Methyl-1,4-naphthalenedione-d8; 2-Methyl-1,4-dihydro-1,4-diketonaphthalene-d8; 2-Methyl-1,4-naphthoquinone (octadeuterated); 2-Methyl-1,4-naphthoquinone (D8); 2-Methyl-1,4-naphthoquinone-d8; 2-Methylnaphthoquinone-d8
EINECS	Contact for details

Quality Control

Our 2-Methyl-1,4-Naphthoquinone-D8 is produced under strict quality management systems to ensure the highest isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR and Mass Spectrometry to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98% D), chemical purity (by HPLC), and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and tendency to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.