Description

2-Chloro-2,2-Difluoro-1-(1H-Indol-3-Yl)-1-Ethanol is a high-value fluorinated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both chloro and difluoro substituents on the ethanol side chain, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and oncology indications.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the introduction of fluorine atoms can enhance biological activity and environmental stability.
• Material Science Research: Acts as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Academic & R&D Laboratories: Serves as a versatile reagent for methodological studies in organic chemistry, especially in fluorination and cross-coupling reactions.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for scale-up and production under GMP or non-GMP conditions for client projects.

Basic Information

Product Name	2-Chloro-2,2-Difluoro-1-(1H-Indol-3-Yl)-1-Ethanol
CAS No.	478079-28-6
Molecular Formula	C10H8ClF2NO
Molecular Weight	231.63 g/mol
Synonyms	2-Chloro-2,2-difluoro-1-(1H-indol-3-yl)ethanol; 1-(1H-Indol-3-yl)-2-chloro-2,2-difluoroethanol; 3-(2-Chloro-2,2-difluoro-1-hydroxyethyl)-1H-indole; 2-Chloro-2,2-difluoro-1-(indol-3-yl)ethanol; 478079-28-6; 2-Chloro-2,2-difluoro-1-(1H-indol-3-yl)ethan-1-ol
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-2,2-Difluoro-1-(1H-Indol-3-Yl)-1-Ethanol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.