Description

Ethanone, 2-Chloro-2,2-Difluoro-1-(1H-Indol-3-Yl)- (9Ci) is a high-purity, fluorinated indole derivative serving as a critical advanced intermediate in modern synthetic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce difluoromethyl and chloroacetyl motifs into indole-based scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used in developing new generation herbicides, fungicides, and plant growth regulators that leverage the biological activity of the fluorinated indole structure.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialized polymers and organic electronic materials.
• Chemical Biology Probe Development: Utilized to create labeled compounds or activity-based probes for studying enzyme mechanisms and biological pathways.
• Academic & Contract Research: Essential for methodological development in organic synthesis, including novel fluorination and cross-coupling reactions.

Basic Information

Item	Details
Product Name	Ethanone, 2-Chloro-2,2-Difluoro-1-(1H-Indol-3-Yl)- (9Ci)
CAS No.	478065-02-0
Molecular Formula	C10H6ClF2NO
Molecular Weight	229.61 g/mol
Synonyms	2-Chloro-2,2-difluoro-1-(1H-indol-3-yl)ethanone; 3-(2-Chloro-2,2-difluoroacetyl)indole; 1H-Indole-3-acetyl chloride, 2,2-difluoro-; 2-Chloro-2,2-difluoro-1-(indol-3-yl)ethanone; 478065-02-0; 2,2-Difluoro-2-chloro-1-(1H-indol-3-yl)ethanone
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-2,2-Difluoro-1-(1H-Indol-3-Yl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.