Description

3-[3,4-Dihydro-2(1H)-Isoquinolinyl]-1,1,1-Trifluoro-2-Propanol is a high-value, fluorinated organic compound featuring a fused isoquinoline scaffold, making it a versatile building block for advanced chemical synthesis. Its molecular structure, combining a trifluoromethyl group with a heterocyclic amine, is engineered to impart unique physicochemical properties critical for developing novel active ingredients. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for use as a key intermediate in the creation of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science: Acts as a monomer or functional additive in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry for constructing complex ligands used in asymmetric catalysis and transition metal complexes.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the introduction of fluorine atoms into complex molecular architectures.
• Chemical Library Synthesis: Utilized in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.

Basic Information

Product Name	3-[3,4-Dihydro-2(1H)-Isoquinolinyl]-1,1,1-Trifluoro-2-Propanol
CAS No.	478050-27-0
Molecular Formula	C12H12F3NO
Molecular Weight	243.22 g/mol
Synonyms	1,1,1-Trifluoro-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-ol; 2-Propanol, 3-[3,4-dihydro-2(1H)-isoquinolinyl]-1,1,1-trifluoro-; 3-(3,4-Dihydro-1H-isoquinolin-2-yl)-1,1,1-trifluoropropan-2-ol; 1,1,1-Trifluoro-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ol; TFIQP; Fluorinated Isoquinolinyl Propanol; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 3-[3,4-Dihydro-2(1H)-Isoquinolinyl]-1,1,1-Trifluoro-2-Propanol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and regulatory compliance (REACH, TSCA) ensures a reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.