Description

(E)-1-(4-Methyl-2-Phenyl-1,3-Thiazol-5-Yl)-3-(3-Pyridinylamino)-2-Propen-1-One is a high-purity, synthetic organic compound featuring a unique thiazole-pyridine hybrid structure. This compound serves as a critical advanced pharmaceutical intermediate and a versatile research chemical for medicinal chemistry and drug discovery programs. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical, agrochemical, and life science industries for developing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Kinase Inhibitor Development: Used in the research and development of potential kinase inhibitors due to its heterocyclic pharmacophore.
• Agrochemical Research: Intermediate in the synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Serves as a precursor for creating molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale API development.

Basic Information

Product Name	(E)-1-(4-Methyl-2-Phenyl-1,3-Thiazol-5-Yl)-3-(3-Pyridinylamino)-2-Propen-1-One
CAS No.	478047-36-8
Molecular Formula	C18H15N3OS
Molecular Weight	321.40 g/mol
Synonyms	(E)-1-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)-3-(pyridin-3-ylamino)prop-2-en-1-one; 3-Pyridinamine, N-[(1E)-3-(4-methyl-2-phenyl-5-thiazolyl)-3-oxo-1-propen-1-yl]-; (E)-N-(3-(4-Methyl-2-phenylthiazol-5-yl)-3-oxoprop-1-en-1-yl)pyridin-3-amine; Thiazole-pyridine enaminone derivative; 478047-36-8; Enaminone intermediate CAS 478047-36-8
EINECS	Contact for details

Quality Control

Our production of (E)-1-(4-Methyl-2-Phenyl-1,3-Thiazol-5-Yl)-3-(3-Pyridinylamino)-2-Propen-1-One adheres to stringent in-house quality standards to ensure batch-to-batch consistency and reliability for your research and development processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development projects requiring material produced under GMP-like conditions for non-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.