Description

1,8-Naphthyridine-2-Acetonitrile,α-(2-Chlorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring a naphthyridine core, an acetonitrile moiety, and trifluoromethyl groups, makes it a critical intermediate for constructing sophisticated molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold for the synthesis of potential drug candidates, particularly in areas targeting enzymes and receptors where the naphthyridine structure is pharmacologically relevant.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging the biological activity imparted by the trifluoromethyl and chlorophenyl groups.
• Material Science Precursor: Acts as a building block for creating specialized organic ligands or functional molecules used in catalysis or advanced polymeric materials.
• Chemical Biology Probe: Utilized in academic and industrial research to create molecular probes for studying biological processes and target identification.
• Fluorinated Compound Synthesis: The presence of two trifluoromethyl groups makes it a valuable starting material for introducing fluorine into target molecules to enhance metabolic stability, lipophilicity, and bioavailability.

Basic Information

Product Name	1,8-Naphthyridine-2-Acetonitrile,α-(2-Chlorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci)
CAS No.	478043-27-5
Molecular Formula	C₁₉H₉ClF₆N₂
Molecular Weight	414.73 g/mol
Synonyms	α-(2-Chlorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; 2-2-Chlorophenylmethyl]-5,7-bis(trifluoromethyl)-1,8-naphthyridine; 5,7-Bis(trifluoromethyl)-α-(2-chlorophenyl)-1,8-naphthyridine-2-acetonitrile; 1,8-Naphthyridine-2-acetonitrile, α-(2-chlorophenyl)-5,7-bis(trifluoromethyl)-; (9CI); 478043-27-5 (CAS)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.