Description

1-[2-(1H-Indol-3-Yl)-Ethyl]-2-Methyl-5-Oxo-4,5-Dihydro-1H-Pyrrole-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture combining indole and pyrrolidone moieties. This compound is of significant commercial interest for its role as a key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex heterocyclic compounds targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of proprietary drug candidates, particularly those with complex polycyclic structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for developing new therapeutic agents.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for scale-up synthesis and process development under cGMP guidelines.
• Biochemical Research: Employed as a reference standard or a reagent in biochemical assays exploring enzyme inhibition or receptor binding.
• Academic Research: Utilized in university and institutional labs for synthetic methodology development and heterocyclic chemistry studies.

Basic Information

Item	Details
Product Name	1-[2-(1H-Indol-3-Yl)-Ethyl]-2-Methyl-5-Oxo-4,5-Dihydro-1H-Pyrrole-3-Carboxylic Acid Methyl Ester
CAS No.	477871-83-3
Molecular Formula	C₁₉H₂₀N₂O₃
Molecular Weight	324.38 g/mol
Synonyms	Methyl 1-[2-(1H-indol-3-yl)ethyl]-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate; 1H-Pyrrole-3-carboxylic acid, 4,5-dihydro-1-[2-(1H-indol-3-yl)ethyl]-2-methyl-5-oxo-, methyl ester; 477871-83-3; Indole-pyrrolidone derivative; Methyl ester of 1-(2-indol-3-ylethyl)-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-[2-(1H-Indol-3-Yl)-Ethyl]-2-Methyl-5-Oxo-4,5-Dihydro-1H-Pyrrole-3-Carboxylic Acid Methyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.