Description

Methyl 5-([3-(Trifluoromethyl)Benzoyl]Amino)-1-Benzothiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its benzothiophene core and trifluoromethyl-substituted benzamide moiety. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for applications in oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Protease Inhibitor Development: The molecular structure suggests utility in the design and synthesis of protease inhibitors, a major class of therapeutic agents.
• Kinase Inhibitor Synthesis: Serves as a core component in the creation of novel kinase inhibitors for cancer research and treatment.
• Chemical Biology Probes: Employed in the development of chemical probes to study and modulate biological processes at the molecular level.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	Methyl 5-([3-(Trifluoromethyl)Benzoyl]Amino)-1-Benzothiophene-2-Carboxylate
CAS No.	477847-54-4
Molecular Formula	C18H12F3NO3S
Molecular Weight	379.35 g/mol
Synonyms	Methyl 5-[[[3-(trifluoromethyl)phenyl]carbonyl]amino]-1-benzothiophene-2-carboxylate; 5-[(3-Trifluoromethylbenzoyl)amino]benzo[b]thiophene-2-carboxylic acid methyl ester; 1-Benzothiophene-2-carboxylic acid, 5-[[[3-(trifluoromethyl)phenyl]carbonyl]amino]-, methyl ester; Methyl 5-(3-(trifluoromethyl)benzamido)benzo[b]thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 5-([3-(Trifluoromethyl)Benzoyl]Amino)-1-Benzothiophene-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects with material suitable for research use or produced under controlled conditions for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.