Description

(1R)-1-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Ylmethyl)-2,2,2-Trifluoroethyl 2-Thiophenecarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and trifluoroethyl ester structure. This compound is critical for enabling sophisticated synthetic routes in modern drug discovery, particularly for introducing specific stereochemistry and fluorine-containing motifs known to enhance metabolic stability and bioavailability. It is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the spirocyclic and fluorine components can contribute to unique biological activity.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating labeled or tagged molecules used to study biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex organic molecules.
• Material Science Research: Potential monomer or precursor for specialized polymers with tailored electronic or surface properties.

Basic Information

Product Name	(1R)-1-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Ylmethyl)-2,2,2-Trifluoroethyl 2-Thiophenecarboxylate
CAS No.	477762-57-5
Molecular Formula	C15H18F3NO4S
Molecular Weight	365.37 g/mol
Synonyms	(R)-1-((1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)methyl)-2,2,2-trifluoroethyl thiophene-2-carboxylate; 2-Thiophenecarboxylic acid (1R)-1-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-2,2,2-trifluoroethyl ester; 8-(((R)-2,2,2-Trifluoro-1-(thiophene-2-carbonyloxy)ethyl)methyl)-1,4-dioxa-8-azaspiro[4.5]decane; (1R)-1-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2,2,2-trifluoroethyl 2-thiophenecarboxylate; Trifluoroethyl thiophenecarboxylate spirocyclic intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) specifying results for chiral purity (HPLC), assay, and related substances is supplied with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.