Description

Carbamic Acid, [(1R)-2-Amino-1-(Mercaptomethyl)-2-Oxoethyl]-, 1,1- is a specialized chiral building block featuring both carbamate and thiol functionalities. This compound is of significant value in advanced pharmaceutical synthesis and biochemical research due to its unique stereochemistry and reactive groups. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecules, particularly in peptide mimetics and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology and neurology.
• Peptidomimetic Research: Used to introduce constrained, cysteine-like structures into peptide backbones to enhance stability and biological activity.
• Bioconjugation Chemistry: The free thiol group enables site-specific conjugation to proteins, antibodies, or nanoparticles for drug delivery systems.
• Ligand Synthesis for Catalysis: Serves as a precursor for chiral ligands used in asymmetric synthesis catalysts.
• Protease Inhibitor Development: Incorporated into molecular scaffolds designed to inhibit specific enzymes.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes for studying enzyme function and mechanism.

Basic Information

Product Name	Carbamic Acid, [(1R)-2-Amino-1-(Mercaptomethyl)-2-Oxoethyl]-, 1,1-
CAS No.	476639-84-6
Molecular Formula	C5H8N2O3S
Molecular Weight	176.19 g/mol
Synonyms	(2R)-2-[(Aminocarbonyl)amino]-3-mercaptopropanoic acid; D-2-[(Aminocarbonyl)amino]-3-mercaptopropanoic acid; (R)-2-Carbamoylamino-3-mercaptopropionic acid; (1R)-2-Amino-1-(mercaptomethyl)-2-oxoethyl carbamate; N-Carbamoyl-D-cysteine; D-Cysteine, N-carboxy-; Chiral cysteine carbamate derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing. Identity, purity, and chiral integrity are verified through a suite of analytical techniques including HPLC, NMR, and optical rotation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.