Description

Isoquinoline, 7,8-Difluoro- (9Ci) is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is a critical strategy for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the discovery and synthesis of new-generation herbicides, fungicides, and insecticides, where the difluoro-isoquinoline scaffold can enhance potency and environmental persistence.
• Material Science & OLED Development: Serves as an electron-transporting or host material precursor in the manufacture of organic light-emitting diodes (OLEDs) and other advanced electronic materials.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized nitrogen-containing ligands for transition metal catalysis, enabling novel synthetic transformations.
• Fluorescent Probe & Dye Chemistry: Acts as a core structure for developing novel fluorescent markers and dyes used in biochemical sensing and imaging applications.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling and fluorination reactions.

Basic Information

Product Name	Isoquinoline, 7,8-Difluoro- (9Ci)
CAS No.	475994-57-1
Molecular Formula	C9H5F2N
Molecular Weight	165.14 g/mol
Synonyms	7,8-Difluoro-isoquinoline; 7,8-Difluoro-isoquinoline (9CI); 7,8-Difluoro-isoquinoline, 9CI; 7,8-Difluoroisoquinoline; Isoquinoline, 7,8-difluoro-; 7,8-Difluoro-1-azanaphthalene; 7,8-Difluorobenzo[f]quinoline (incorrect but common misnomer); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Isoquinoline, 7,8-Difluoro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for cGMP and ISO-guided applications in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Purity (GC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.