Description

2-Pentanone, 5,5-Difluoro-4-Hydroxy- (9Ci) is a specialized fluorinated ketone building block with a unique difluoromethyl-hydroxy functional group. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. It is primarily sought by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro moiety enhances lipophilicity and environmental stability.
• Fluorine Chemistry & Material Science: Serves as a versatile precursor for creating fluorinated polymers, liquid crystals, and specialty materials with tailored surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic additions, and as a scaffold for constructing complex, fluorinated molecular architectures in medicinal chemistry programs.
• Chemical Research & Development: Essential for academic and industrial R&D labs exploring new synthetic methodologies and the structure-activity relationships (SAR) of fluorinated compounds.

Basic Information

Product Name	2-Pentanone, 5,5-Difluoro-4-Hydroxy- (9Ci)
CAS No.	475659-74-6
Molecular Formula	C5H8F2O2
Molecular Weight	138.11 g/mol
Synonyms	5,5-Difluoro-4-hydroxypentan-2-one; 4-Hydroxy-5,5-difluoropentan-2-one; 5,5-Difluoro-4-hydroxypentan-2-one (9CI); 5,5-Difluoro-4-hydroxy-2-pentanone; 1,1-Difluoro-3-acetyl-1-hydroxypropane
EINECS	Contact for details

Quality Control

Our 2-Pentanone, 5,5-Difluoro-4-Hydroxy- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. Due to its functional groups, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.