Description

Fmoc-4-Aminobenzylalcohol CAS NO 475160-83-9 is a protected amino alcohol derivative, serving as a crucial bifunctional building block in organic synthesis. Its value lies in providing orthogonal protection for amine and alcohol functionalities, enabling precise, sequential reactions in complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the solid-phase synthesis of peptides and peptidomimetics, as well as in medicinal chemistry for creating novel chemical libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for introducing the 4-aminobenzyl alcohol (Pab) linker, which is cleavable for generating peptide C-terminal amides or hydroxamates.
• Protecting Group Strategy: Utilized in multi-step organic synthesis where selective deprotection of the Fmoc group (base-labile) is required while the alcohol remains protected, or vice-versa.
• Combinatorial Chemistry: Serves as a versatile scaffold for generating diverse arrays of small molecules and peptides in drug discovery programs.
• Linker Chemistry for Resin Functionalization: Used to prepare specialty resins for solid-supported synthesis, offering a handle for subsequent cleavage under specific conditions.
• Synthesis of Drug Conjugates: Acts as a spacer or linker in the design of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Material Science Precursor: Can be employed in the synthesis of functionalized polymers or dendrimers with tailored surface amine/alcohol groups.

Basic Information

Product Name	Fmoc-4-Aminobenzylalcohol
CAS No.	475160-83-9
Molecular Formula	C22H19NO3
Molecular Weight	345.39 g/mol
Synonyms	Fmoc-Pab-OH; N-(9-Fluorenylmethoxycarbonyl)-4-aminobenzyl alcohol; 4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]benzenemethanol; Fmoc-4-Abz-OH; Nα-Fmoc-4-aminobenzyl alcohol; Fmoc-4-Aminobenzyl Alcohol; N-Fmoc-4-aminobenzylalcohol; 4-(Fmoc-amino)benzyl alcohol
EINECS	Contact for details

Quality Control

Our Fmoc-4-Aminobenzylalcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR) for structural confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.