Description

2-(4-Fluoro-Benzenesulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonylated tetrahydroisoquinoline carboxylic acid structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential active pharmaceutical ingredients (APIs) with targeted biological activity.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design of enzyme inhibitors, leveraging the sulfonyl and carboxylic acid functional groups.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and novel heterocycle formation.

Basic Information

Product Name	2-(4-Fluoro-Benzenesulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
CAS No.	475041-45-3
Molecular Formula	C₁₆H₁₄FNO₄S
Molecular Weight	335.35 g/mol
Synonyms	2-[(4-Fluorophenyl)sulfonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-2-[(4-fluorophenyl)sulfonyl]-3-isoquinolinecarboxylic Acid; 2-(4-Fluorobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 475041-45-3; UNII-9F6J6WQ8QN; 9F6J6WQ8QN; SCHEMBL218422; DTXSID60636688; BCP13833; AS-81233; STK387086; AKOS040750232.
EINECS	Contact for details

Quality Control

Our 2-(4-Fluoro-Benzenesulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with good laboratory practices for chemicals.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.